A SYNTHETIC HYDROGEL AND ITS USE FOR IMMUNOTHERAPY AND 3D-PRINTING

The present invention discloses a hydrogel comprising a functionalized PEG multi- arm star polymer covalently combined with maleimide-functionalized low molecular weight heparin, further comprising at least one positively charged immune molecule, a method for producing this hydrogel and its use in T...

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Main Authors VECIANA MIRÓ, Jaume, ENGEL LÓPEZ, Elisabeth, PÉREZ DEL RÍO, Eduardo, RODRÍGUEZ RODRÍGUEZ, Xavier, GUASCH CAMELL, Judit, MARTINEZ MIGUEL, Marc, SANTOS ABREU, Roberto Fabião, MATEOS TIMONEDA, Miguel Ángel, RATERA BASTARDAS, Imma
Format Patent
LanguageEnglish
French
Published 25.11.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention discloses a hydrogel comprising a functionalized PEG multi- arm star polymer covalently combined with maleimide-functionalized low molecular weight heparin, further comprising at least one positively charged immune molecule, a method for producing this hydrogel and its use in T cell culture for immunotherapies. Furthermore, the invention relates to a bioink and its use in 3D-(bio)-printing. La présente invention concerne un hydrogel comprenant un polymère en étoile multi-bras PEG fonctionnalisé combiné de manière covalente avec de l'héparine de faible poids moléculaire fonctionnalisé par maléimide, comprenant en outre au moins une molécule immunitaire chargée positivement, un procédé de production de cet hydrogel et son utilisation dans la culture de lymphocytes T pour des immunothérapies. En outre, l'invention concerne une bioencre et son utilisation dans la (bio)-impression 3D.
Bibliography:Application Number: WO2021EP63643