CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS12B

Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations there...

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Bibliographic Details
Main Authors REISS, Caroline, CHADWICK, Alexandra, RAJEEV, Kallanthottathil
Format Patent
LanguageEnglish
French
Published 18.11.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations thereto. L'invention concerne des compositions associées à des ARN guides de Cas12b. L'invention concerne également des méthodes de modification de séquences de polynucléotides cibles et des méthodes de traitement ou de prévention d'un état chez un sujet qui en a besoin, tel que des états consécutifs à l'expression de ANGPTL3 ou de ses mutations.
Bibliography:Application Number: WO2021US26655