CARRIERS FOR EFFICIENT NUCLEIC ACID DELIVERY

• Main Authors: RUPING, Karl, CHAHAL, Jasdave, HUANG, Jin, TALUKDER, Poulami
• Format: Patent
• Language: English; French
• Published: 14.10.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising polyester (PE) dendrimers or dendrons, and therapeutic or immunogenic nucleic acid agents enclosed within the PE are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided. Sont décrites, des compositions de nanoparticules destinées à l'administration d'acides nucléiques à des sujets, comprenant des vecteurs comprenant des dendrimères ou des dendrons de polyester (PE), et des agents acides nucléiques thérapeutiques ou immunogènes enfermés dans le PE. L'invention concerne également des méthodes de traitement ou de prévention de maladies ou d'états chez un sujet par administration des compositions de nanoparticules qui fournissent des réponses immunitaires et des effets thérapeutiques ou préventifs synergiques.