PYRROLO[2,3-F]INDAZOLE AND 2,4,5,10-TETRAZATRICYCLO[7.3.0.03,7]DODECA-1,3(7),5,8,11-PENTAENE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)

• Main Authors: HALL, Amy B, COTTRELL, Kevin Michael, BRODNEY, Michael Aaron, BOYD, Michael John, ZAKY, Mariam, GARCIA BARRANTES, Pedro Manuel, JOHNSON, JR, HURLEY, Dennis James, BOUCHER, Diane Marie, MAXWELL, John Patrick, XU, Jinwang, DAMAGNEZ, Veronique, KESAVAN, Sarathy, JONES, Peter, TAPLEY, Timothy Lewis, FIMOGNARI, JR, GREY, JR, THOMSON, Stephen A, FANNING, Lev T, SWETT, Rebecca Jane, GIROUX, Simon, NUHANT, Philippe Marcel
• Format: Patent
• Language: English; French
• Published: 07.10.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-l,3(7),5,8,ll-pentaene derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD) L'invention concerne des dérivés de pyrrolo[2,3-f]indazole et de 2,4,5,10-tétrazatricyclo[7.3.0.03,7]dodéca-l,3(7),5,8,ll-pentaène en tant que modulateurs d'alpha-1-antitrypsine pour traiter une déficience en alpha-1-antitrypsine (AATD).