DUAL-TARGETING CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS COMPRISING IL-13 AND CHLOROTOXIN FOR CANCER TREATMENT

Chimeric antigen receptors having a chlorotoxin domain and an IL-13 are described. These dual targeted chimeric antigen receptors are useful for treating glioblastoma and other cancers of neuroectodermal origin. L'invention concerne des récepteurs antigéniques chimériques ayant un domaine chlor...

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Bibliographic Details
Main Authors WANG, Dongrui, FORMAN, Stephen J, BARISH, Michael, BROWN, Christine E
Format Patent
LanguageEnglish
French
Published 16.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Chimeric antigen receptors having a chlorotoxin domain and an IL-13 are described. These dual targeted chimeric antigen receptors are useful for treating glioblastoma and other cancers of neuroectodermal origin. L'invention concerne des récepteurs antigéniques chimériques ayant un domaine chlorotoxine et un domaine IL-13. Ces récepteurs antigéniques chimériques à double ciblage sont utiles pour traiter le glioblastome et d'autres cancers d'origine neuroectodermique.
Bibliography:Application Number: WO2021US21890