ANTI D-DIMER RECOMBINANT ANTIBODIES, METHODS AND USES THEREOF

This application relates to anti-D-Dimer recombinant antibodies that specifically bind to fibrin and fibrinogen degradation products (FDP) such as D-Dimer, fragment DD and fragment D with high binding affinity and do not bind to fragment E and fibrinogen. The present invention also refers to methods...

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Bibliographic Details
Main Authors HOLZ, Charles, BOOTH, Elizabeth A, MONTANINI, Virginia, WASLEY, Tristan, BERRY, Jody
Format Patent
LanguageEnglish
French
Published 26.08.2021
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:This application relates to anti-D-Dimer recombinant antibodies that specifically bind to fibrin and fibrinogen degradation products (FDP) such as D-Dimer, fragment DD and fragment D with high binding affinity and do not bind to fragment E and fibrinogen. The present invention also refers to methods and assays for detection of D-Dimer and FDP fragments in samples using said recombinant antibodies. Cette invention concerne des anticorps recombinants anti-D-dimère qui se lient spécifiquement à des produits de dégradation de la fibrine et du fibrinogène (FDP) tel que le D-dimère, le fragment DD et le fragment D présentant une affinité de liaison élevée et ne se liant pas au fragment E ni au fibrinogène. La présente invention concerne également des procédés et des dosages pour la détection de fragments D-dimères et FDP dans des échantillons à l'aide desdits anticorps recombinants.
Bibliography:Application Number: WO2021IB51438