SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME

• Main Authors: GAGNON, Kevin James, MINCHOM, Jack Raphael, PERESYPKIN, Andrey, JUDELSON, Michael David, MEDEK, Ales, LAI, Mei-Hsiu, WITKOS, Faith, SARPAL, Kanika, LI, Jicong, SHI, Yi, SHRESTHA, Muna, MAGUIRE, Courtney K, IYEMPERUMAL, Satish Kumar
• Format: Patent
• Language: English; French
• Published: 12.08.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure provides novel solid state forms of Compound (I) selected from Form B, citric acid cocrystal Form A, piperazine cocrystal Form A, urea cocrystal Form A, nicotinamide cocrystal Form A, nicotinamide cocrystal Form B, aspartame cocrystal Form A, glutaric acid cocrystal Form A, L-proline cocrystal Form A, L-proline cocrystal Form B, vanillin cocrystal Form A, and 2-pyridone cocrystal Form A, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease. La présente divulgation concerne de nouvelles formes à l'état solide du composé (I) choisi parmi la forme B, la forme A du cocristal d'acide citrique, la pipérazine A, la forme A du cocristal d'urée, la forme A du cocristal de nicotinamide, la forme B du cocristal de nicotinamide, la forme A du cocristal de l'aspartame, la forme A du cocristal de l'acide glutarique, la forme A du cocristal de L-proline, la forme B du cocristal de L-proline, la forme A du cocristal de la vanilline, et la forme A du cocristal de 2-pyridone, des compositions les comprenant, et des procédés d'utilisation associés, comprenant l'utilisation dans le traitement d'une maladie rénale à médiation par APOL1.