CELL-DERIVED VESICLES COMPRISING TARGET PROTEIN AND METHOD FOR PRODUCING SAME

• Main Authors: OH, Seung Wook, PARK, Tae Sub, BAE, Shin Gyu, PARK, Joong Hoon
• Format: Patent
• Language: English; French; Korean
• Published: 22.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The present invention relates to cell-derived vesicles comprising target protein Prokineticin receptor 1 (PROKR1), and a therapeutic agent for muscle diseases comprising the same. When applied to myoblasts, the cell-derived vesicles comprising PROKR1 according to the present invention promote muscle differentiation and induce differentiation into myotubes, and can thus be used to prevent or treat muscle diseases and can be widely used in the pharmaceutical industry and the field of health functional foods. La présente invention concerne des vésicules dérivées de cellules comprenant le récepteur 1 de protéine cible prokinéticine (PROKR1) et un agent thérapeutique pour des maladies musculaires les comprenant. Lorsqu'appliquées à des myoblastes, les vésicules dérivées de cellules comprenant PROKR1 selon la présente invention favorisent la différenciation musculaire et induisent la différenciation en myotubes et peuvent ainsi être utilisées pour prévenir ou traiter des maladies musculaires et peuvent être largement utilisées dans l'industrie pharmaceutique et dans le domaine des aliments fonctionnels de santé. 본 발명은 표적 단백질인 PROKR1을 포함하는 세포 유래 베시클 및 이를 포함하는 근 질환 치료제에 관한 것이다. 본 발명에 따른 PROKR1 (Prokineticin receptor 1)을 포함하는 세포 유래 베시클은 근모세포에 처리되었을 때, 근분화를 촉진하고, 근관세포로의 분화를 유도하여, 근 질환을 예방 또는 치료하는 용도로 사용할 수 있어, 의약업계 및 건강기능식품 분야에서 널리 사용될 수 있다.