PROGRANULIN VARIANTS

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein. L'...

Full description

Saved in:
Bibliographic Details
Main Authors PROROK, Rachel, KANNAN, Gunasekaran, SRIVASTAVA, Ankita, LOW, Ray L.Y, CHERF, Gerald Maxwell, LEXA, Katrina W
Format Patent
LanguageEnglish
French
Published 01.07.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein. L'invention concerne des variants de la progranuline et des protéines de fusion qui comprennent un variant de progranuline et un polypeptide Fc. L'invention concerne également des procédés d'utilisation de ces protéines pour traiter des troubles associés à la progranuline (par exemple une maladie neurodégénérative, telle que la démence frontotemporale (FTD)).
Bibliography:Application Number: WO2020US66831