MICROORGANISM COMPRISING GENETIC MODIFICATION THAT INCREASES ACTIVITY OF MULTIDRUG TRANSPORTER, AND METHOD FOR PRODUCING TRYPTOPHAN METABOLITES BY USING SAME

• Main Authors: RYU, Gyu Ri, JEON, Ae Ji, BAE, Hyun Ae, JANG, Jae Woo
• Format: Patent
• Language: English; French; Korean
• Published: 24.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Disclosed is a recombinant microorganism comprising a genetic modification that increases the activity of a multidrug transporter A (multidrug efflux system subunit A: MdtA). A recombinant microorganism comprising genetic modification that increases the activity of a multidrug transporter and a method for producing tryptophan metabolites by using same enable mass-production of tryptophan metabolites. L'invention concerne un micro-organisme recombinant comprenant une modification génétique qui augmente l'activité d'un transporteur de médicaments multiples A (sous-unité A de système d'efflux de médicaments multiples : MdtA). Un micro-organisme recombinant comprenant une modification génétique qui augmente l'activité d'un transporteur de médicaments multiples et un procédé de production de métabolites de tryptophane à l'aide de celui-ci permettent la production en masse de métabolites de tryptophane. 다중약물 수송체 A(Multidrug efflux system subunit A: MdtA)의 활성을 증가시키는 유전적 변형(genetic modification)을 포함하는 재조합 미생물에 관한 것이다. 다중약물 수송체의 활성을 증가시키는 유전적 변형을 포함하는 재조합 미생물, 및 그를 이용한 트립토판 대사체를 생산하는 방법은 트립토판 대사체의 대량 생산을 가능하게 할 수 있다.