PROCESS FOR THE PREPARATION OF A CHIRAL PROSTAGLANDIN ENOL INTERMEDIATE AND INTERMEDIATE COMPOUNDS USEFUL IN THE PROCESS

• Main Authors: LÁSZLÓFI, István, TAKÁCS, László, MELEG, Ildikó, KARDOS, Zsuzsanna, KERTÉSZ, Máriusz, SÁNTÁNÉ CSUTOR, Andrea, HORTOBÁGYI, Irén, PÓTI, Judit
• Format: Patent
• Language: English; French
• Published: 24.06.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to a process for the preparation of a chiral prostaglandin enol intermediate of formula 1, comprising the steps of: separating a compound of formula 16-(R,S)-10 into its diastereomers by fractional crystallisation, reducing the 15-oxo group of the compound of formula 16...