NANOSTRUCTURED DRUG DELIVERY SYSTEM AS A MULTIFUNCTIONAL PLATFORM FOR THERAPY

• Main Authors: CARIA CANELAS PAIS, Alberto António, LEITÃO DAS NEVES ALMEIDA, António José, DA CRUZ NUNES, Sandra Cristina, DIOGO GONÇALVES, Lídia Maria, CELTA FALCÃO RAMOS FERREIRA, Amílcar, MARTINS SIMÕES DE SOUSA, João José, PINHEIRO VITORINO, Carla Sofia, BASSO DA SILVA TORRES, João Diogo, BAIRRADA FORTUNA, Ana Cristina, FELICIANO DA COSTA MENDES, Maria Manuel, FIRMINO GUERRA GUERREIRO COVA, Tânia
• Format: Patent
• Language: English; French
• Published: 10.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The present invention discloses a drug delivery system for targeted therapy comprising a functionalized lipid-based nanoplatform, where at least one ligand is coupled to the surface of the nanoplatform and encapsulates at least one pharmaceutically active ingredient. A process for obtaining the drug delivery system of the present invention is also disclosed as well as a composition comprising the system of the invention. The invention relates to the field of medicine and biotechnology. The present solution aims at developing targeting co-encapsulating nanostructured lipid carriers for the treatment of different types of cancer, including glioblastoma, as well as other diseases and disorders, envisioning the establishment of an in vitro/in vivo correlation. La présente invention concerne un système d'administration de médicament pour une thérapie ciblée comprenant une nanoplateforme fonctionnalisée à base de lipides, au moins un ligand étant accouplé à la surface de la nanoplateforme et encapsulant au moins un ingrédient pharmaceutiquement actif. L'invention concerne également un procédé d'obtention du système d'administration de médicament de la présente invention ainsi qu'une composition comprenant le système de l'invention. L'invention concerne les domaines de la médecine et de la biotechnologie. La présente solution vise à mettre au point des vecteurs lipidiques nanostructurés de co-encapsulation de ciblage pour le traitement de différents types de cancer, y compris le glioblastome, ainsi que d'autres maladies et troubles, envisageant l'établissement d'une corrélation in vitro/in vivo.