MONOCLONAL CELL LINES EXPRESSING AN EXOGENOUS SUBSTANCE AND USES THEREOF

Described herein are genetically modified cells derived from a human cell and which contain at least one exogenous transcription unit inserted into at least one of four open chromatin regions (OCRs) located on Chromosomes 2, 5, 8 and 12, as well as compositions, pharmaceutical preparations, and impl...

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Bibliographic Details
Main Authors CARMONA, Guillaume, SEWELL, Jared, BARNEY, Lauren, PAPAKOSTA, Marianthi
Format Patent
LanguageEnglish
French
Published 27.05.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Described herein are genetically modified cells derived from a human cell and which contain at least one exogenous transcription unit inserted into at least one of four open chromatin regions (OCRs) located on Chromosomes 2, 5, 8 and 12, as well as compositions, pharmaceutical preparations, and implantable devices comprising the genetically modified cells, and methods of using the same for preventing or treating a disease, disorder, or condition. L'invention concerne des cellules génétiquement modifiées dérivées d'une cellule humaine et qui contiennent au moins une unité de transcription exogène insérée dans au moins l'une des quatre régions de chromatine ouvertes (TCR) situées sur les chromosomes 2, 5, 8 et 12, ainsi que des compositions, des préparations pharmaceutiques et des dispositifs implantables comprenant les cellules génétiquement modifiées, et leurs méthodes d'utilisation pour prévenir ou traiter une maladie, un trouble ou un état pathologique.
Bibliography:Application Number: WO2020US61524