PROSTAGLANDIN ANALOGS AND USES THEREOF

• Main Authors: RAJAN, Sreekanth, YOON, Ho Sup, YOON, Cheolhwan, KIM, Moonhwan, SEO, Jeongbeob, HAN, Cheolkyu, KANG, Hongjun, YOO, Jun Yeob
• Format: Patent
• Language: English; French
• Published: 14.05.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, including, as an active ingredient, a prostaglandin analog or a pharmaceutically acceptable salt thereof, wherein the compound has excellent effects in inducing Nurr1, and thus, can be useful as a pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, in particular, cancer, autoimmune disease such as rheumatoid arthiritis, schizophrenia, manic depression and neurodegenerative disease such as Alzheimers disease or Parkinson's disease. La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement d'une maladie, trouble, ou un état associé à Nurr1, comprenant, en tant que principe actif, un analogue de prostaglandine ou un sel pharmaceutiquement acceptable de celui-ci, le composé ayant d'excellents effets dans l'induction de Nurr1, et peut ainsi être utile en tant que composition pharmaceutique pour la prévention ou le traitement d'une maladie, de troubles ou d'états associés à Nurr1, en particulier, le cancer, les maladies auto-immunes telles que la polyarthrite rhumatoïde, la schizophrénie, la dépression maniaque et les maladies neurodégénératives telles que la maladie d'Alzheimer ou la maladie de Parkinson.