GABAA POSITIVE ALLOSTERIC MODULATOR COMPOUNDS, METHODS OF MAKING, AND USES THEREOF

• Main Authors: TOCZKO, Matthew, HUBBS, Jed, LIU, Xianglei, NING, YuXi, LI, Zheng Jane, HE, Yunliang
• Format: Patent
• Language: English; French
• Published: 29.04.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In...