GABAA POSITIVE ALLOSTERIC MODULATOR COMPOUNDS, METHODS OF MAKING, AND USES THEREOF

Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In...

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Bibliographic Details
Main Authors TOCZKO, Matthew, HUBBS, Jed, LIU, Xianglei, NING, YuXi, LI, Zheng Jane, HE, Yunliang
Format Patent
LanguageEnglish
French
Published 29.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Also described herein are methods of making and using the same. L'invention concerne des polymorphes comprenant 2',6-difluoro-5'-[3-(1-hydroxy-1-méthyléthyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphényl-2-carbonitrile (TPA023B) ou des sels de ceux-ci. Selon un aspect, l'invention concerne un sel ou co-cristal polymorphe cristallin de TPA023B avec de l'acide phosphorique. Selon un autre aspect, l'invention concerne un sel ou co-cristal polymorphe cristallin de TPA023B avec de l'acide sulfurique. L'invention concerne également des procédés de production et d'utilisation associés.
Bibliography:Application Number: WO2020US56750