COMPOSITIONS, SYSTEMS, AND METHODS FOR IDENTIFYING A COMPOUND THAT MODULATES ONE OR MORE CHARACTERISTICS ASSOCIATED WITH A RBM20 CONDENSATE AND/OR A RBM20 POLYPEPTIDE

The present disclosure, in some aspects, is directed to methods for screening and identifying compounds that modulate one or more characteristics associated with a condensate comprising a RBM20 polypeptide and/or the RBM20 polypeptide. In other aspects, the disclosure is directed to systems and comp...

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Bibliographic Details
Main Authors DANDLIKER, Peter Jeffrey, KWONG, Ann D, MURCKO, Mark Andrew, HALE, Stephen Paul, PATEL, Avinash, MANTEIGA, John C, BEUTEL, Bruce Aaron, WIJAYA, Juwina, KESIĆ, Božena
Format Patent
LanguageEnglish
French
Published 27.05.2021
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The present disclosure, in some aspects, is directed to methods for screening and identifying compounds that modulate one or more characteristics associated with a condensate comprising a RBM20 polypeptide and/or the RBM20 polypeptide. In other aspects, the disclosure is directed to systems and composition components thereof, such as cellular models useful for the methods described herein. Dans certains aspects, la présente invention concerne des procédés de criblage et d'identification de composés qui modulent une ou plusieurs caractéristiques associées à un condensat comprenant un polypeptide RBM20 et/ou le polypeptide RBM20. Dans d'autres aspects, l'invention concerne des systèmes et des composants de composition associés, tels que des modèles cellulaires utiles pour les procédés de l'invention.
Bibliography:Application Number: WO2020US51329