METHODS OF PREPARING T CELLS FOR T CELL THERAPY

Provided herein are methods for preparing T cells for T cell therapy comprising contacting a cell population at a predetermined cell density, with a concentration of an anti- CD3/CD28 nanomatrix and culturing the cells thereby producing a T cell population comprising an increased percentage of at le...

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Bibliographic Details
Main Authors ZHANG, Chupei, PERTEL, Thomas Charles, NI, Yajin, LEONARD, Mark W
Format Patent
LanguageEnglish
French
Published 07.10.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are methods for preparing T cells for T cell therapy comprising contacting a cell population at a predetermined cell density, with a concentration of an anti- CD3/CD28 nanomatrix and culturing the cells thereby producing a T cell population comprising an increased percentage of at least one T cell subtype. In some embodiments, the method increases the percentage of stem memory T cells. L'invention concerne des procédés de préparation de lymphocytes T pour une thérapie par lymphocytes T comprenant la mise en contact d'une population cellulaire à une densité cellulaire prédéterminée, avec une concentration d'une nanomatrice anti-CD3/CD28 et la culture des cellules, ce qui permet de produire une population de lymphocytes T comprenant un pourcentage accru d'au moins un sous-type de lymphocytes T. Dans certains modes de réalisation, le procédé augmente le pourcentage de lymphocytes T de mémoire souches.
Bibliography:Application Number: WO2020US49074