COMPOUND INHIBITING AND INDUCING DEGRADATION OF EGFR AND ALK

• Main Authors: WANG, Hongjun, FAN, Futian, LIU, Kai, WANG, Yeming, XIE, Yong, LIANG, Huining, ZHAO, Yanping, JIANG, Yuanyuan, FENG, Zewang, WANG, Xiaoqian, LIU, Xuelian, ZHANG, Yanhao
• Format: Patent
• Language: Chinese; English; French
• Published: 04.03.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A new compound of general formula (X) inhibiting and inducing degradation of an EGFR and ALK, and a pharmaceutical composition containing said compound. The compound and the pharmaceutical composition can be used for treating diseases related to the EGFR and the ALK kinase, such as cancer. The present invention further provides the preparation and use of the compound. L'invention concerne un nouveau composé de formule générale (X) inhibant et induisant la dégradation d'EGFR et d'ALK, et une composition pharmaceutique contenant ledit composé. Le composé et la composition pharmaceutique peuvent être utilisés pour traiter des maladies associées à EGFR et ALK kinase, telles que le cancer. La présente invention concerne en outre la préparation et l'utilisation du composé. 一种通式(X)的新的抑制并诱导降解EGFR和ALK的化合物，以及含有所述化合物的药物组合物，它们可用于治疗与EGFR和ALK激酶相关的疾病，例如癌症，及上述化合物的制备和用途。