ANTI-TIE2 ANTIBODY AND USE THEREOF

• Main Authors: LEE, Weon Sup, KANG, Nu Ri, PARK, Cheonho, PARK, Beom Yong, YOO, Jin-San, KIM, Do-Yun, LEE, Eun-Ah, LEE, Youngae
• Format: Patent
• Language: English; French; Korean
• Published: 07.10.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to an antibody, which specifically binds to tyrosine-protein kinase receptor TIE-2 (TIE2) so as to possess functions of blood vessel normalization and stabilization through receptor phosphorylation, and relates to: an anti-TIE2 antibody; a nucleic acid encoding same; a vector comprising the nucleic acid; a cell transformed with the vector; a method for preparing the antibody; an agent for stabilizing blood vessels and a composition for treating angiogenesis-associated diseases, both of which comprise the antibody; and a composition for co-administration with a pharmaceutical composition for tumor or cancer treatment and with a composition other than an antibody binding to TIE2. La présente invention concerne un anticorps qui se lie spécifiquement au récepteur de la tyrosine-protéine kinase TIE-2 (TIE2) de manière à posséder des fonctions de normalisation et de stabilisation de vaisseau sanguin par phosphorylation de récepteurs, et concerne : un anticorps anti-TIE2; un acide nucléique codant pour celui-ci; un vecteur comprenant l'acide nucléique; une cellule transformée au moyen du vecteur; un procédé de préparation de l'anticorps; un agent pour stabiliser les vaisseaux sanguins et une composition pour traiter des maladies associées à l'angiogenèse, tous deux comprenant l'anticorps; et une composition permettant la co-administration avec une composition pharmaceutique pour le traitement d'une tumeur ou d'un cancer et avec une composition autre qu'un anticorps se liant à TIE2. 본 발명은 TIE2 (Tyrosine-protein kinase receptor TIE-2)에 특이적으로 결합하여 수용체의 인산화를 통해 혈관을 정상화(vessel normalization)하고, 안정화 (stabilization)시키는 기능을 보유한 항체와 관련된 것으로, 항-TIE2 항체, 이를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 상기 벡터로 형질전환된 세포, 상기 항체의 제조방법, 이를 포함하는 혈관안정화제 및 신생혈관형성(angiogenesis)과 관련된 질병의 치료용 조성물, 종양 또는 암 치료용 약학적 조성물 및 TIE2에 결합하는 항체 이외의 조성물과의 병용투여용 조성물에 관한 것이다.