ANTIBODIES BINDING TO GPRC5D

The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. T...

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Main Authors MAYOUX, Maud Léa, KRAFT, Thomas, KLEIN, Christian, CHRISTOPEIT, Tony, HAEGEL, Hélène Cécile, LORENZ, Stefan, BUJOTZEK, Alexander, FAUTI, Tanja, SCHNEIDER, Anneliese, FERTIG, Georg
Format Patent
LanguageEnglish
French
Published 14.05.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease. La présente invention concerne de manière générale des anticorps qui se lient à GPRC5D, y compris des molécules bispécifiques de liaison à l'antigène, par exemple pour activer des lymphocytes T. De plus, la présente invention concerne des polynucléotides codant pour de tels anticorps, et des vecteurs et des cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des anticorps, et des procédés d'utilisation de ceux-ci dans le traitement d'une maladie.
Bibliography:Application Number: WO2020EP71182