MAGEA10 SPECIFIC T CELL RECEPTORS AND THEIR USE
The present invention relates to an isolated T cell receptor (TCR) specific for a MAGEA10-derived peptide and to a polypeptide comprising a functional portion of the TCR. Further implicated are a multivalent TCR complex, a nucleic acid encoding a TCR, a cell expressing the TCR and a pharmaceutical c...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English French |
Published |
14.01.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to an isolated T cell receptor (TCR) specific for a MAGEA10-derived peptide and to a polypeptide comprising a functional portion of the TCR. Further implicated are a multivalent TCR complex, a nucleic acid encoding a TCR, a cell expressing the TCR and a pharmaceutical composition comprising the TCR. The invention also refers to the TCR for use as a medicament, in particular to the TCR for use in the treatment of cancer.
La présente invention concerne un récepteur de lymphocytes T (TCR) isolé spécifique d'un peptide dérivé de MAGEA10 et un polypeptide comprenant une partie fonctionnelle du TCR. L'invention concerne en outre un complexe TCR multivalent, un acide nucléique codant pour un TCR, une cellule exprimant le TCR et une composition pharmaceutique comprenant le TCR. L'invention concerne également un TCR destiné à être utilisé en tant que médicament, en particulier un TCR destiné à être utilisé dans le traitement du cancer. |
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Bibliography: | Application Number: WO2020EP69246 |