TWO-COMPONENT SYSTEM FOR THE IN SITU PREPARATION OF AN ARTIFICIAL CARTILAGE

• Main Authors: ANTHEUNIS, Harro, WAHNES, Christian, KLUGE, Thomas
• Format: Patent
• Language: English; French
• Published: 14.01.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention relates to a two-component system for the in situ preparation of a polymer network by polymerizing acrylate monomers in the presence of a redox initiator couple comprising an activator and an initiator, the system comprising - a first container with a first component, which first component comprises the activator; and - a second container with a second component, which second component comprises the initiator; wherein the activator and/or the initiator is dissolved in an aqueous buffer solution; and wherein one or both containers further comprise - a water soluble acrylic monomer having one acrylate group; and - a water soluble acrylic monomer having two or more acrylate groups; and - at least one glycosaminoglycan; and wherein the combined water content in both containers is at least 50 wt.%, based on the total weight of the contents of both containers. L'invention concerne un système à deux éléments pour la préparation in situ d'un réseau de polymères par polymérisation de monomères d'acrylate en présence d'un couple initiateur redox comprenant un activateur et un initiateur. Le système comprend : - un premier récipient contenant un premier élément, le premier élément comprenant l'activateur ; et - un second récipient contenant un second élément, le second composant comprenant l'initiateur. L'activateur et/ou l'initiateur sont dissous dans une solution tampon aqueuse. Un ou les deux récipients comprennent en outre : - un monomère acrylique soluble dans l'eau contenant un groupe acrylate ; et - un monomère acrylique hydrosoluble contenant deux groupes acrylate ou plus ; et au moins un glycosaminoglycane, la teneur en eau combinée dans les deux récipients étant d'au moins 50 % en poids, sur la base du poids total du contenu des deux récipients.