RECOMBINANT INTERLEUKIN 12 CONSTRUCT AND USES THEREOF

IL12 fusion proteins containing an IL12 p40 subunit, a linker and an IL12 p35 subunit are described. Also described are nucleic acids encoding the fusion proteins, vectors comprising the nucleic acids, and methods of using the fusion proteins and the nucleic acids encoding the fusion proteins to enh...

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Bibliographic Details
Main Authors HORTON, Helen, BODEN, Daniel, DE POOTER, Dorien
Format Patent
LanguageEnglish
French
Published 24.12.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:IL12 fusion proteins containing an IL12 p40 subunit, a linker and an IL12 p35 subunit are described. Also described are nucleic acids encoding the fusion proteins, vectors comprising the nucleic acids, and methods of using the fusion proteins and the nucleic acids encoding the fusion proteins to enhance immune responses to antigens. L'invention concerne des protéines de fusion IL12 contenant une sous-unité p40 d'IL12, un lieur et une sous-unité p35 d'IL12. L'invention concerne également des acides nucléiques codant pour les protéines de fusion, des vecteurs comprenant les acides nucléiques, et des procédés d'utilisation des protéines de fusion et des acides nucléiques codant pour les protéines de fusion pour améliorer les réponses immunitaires à des antigènes.
Bibliography:Application Number: WO2020IB55705