ANTIBODY TO TIGIT AND USE THEREOF

• Main Authors: PARK, Hye-Young, NAM, Hye Mi, LEE, Jee Won, LEE, Eun Hee, KIM, Mun Kyung, HUR, Min Kyu, SONG, Eun Jung, SHEEN, Joong Hyuk, LIM, So Jung, WON, Jong Hwa, LIM, Ok Jae, YUM, Hye In, LIM, Yang Mi
• Format: Patent
• Language: English; French; Korean
• Published: 17.12.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: an antibody to T cell Immunoreceptor with Ig and Tyrosine-Based Inhibitory Motif Domains (TIGIT), or an antigen-binding fragment thereof; a nucleic acid encoding same; a vector carrying the nucleic acid; a cell transformed with the vector; a method for producing the antibody or the antigen-binding fragment thereof; and a composition and a composition for combined administration, which comprise same and are for preventing or treating cancer. La présente invention concerne : un anticorps dirigé contre un immunorécepteur de cellule T avec des domaines d'Ig et motif inhibiteur à base de tyrosine (TIGIT), ou un fragment de liaison à l'antigène de celui-ci; un acide nucléique codant pour celui-ci; un vecteur portant l'acide nucléique; une cellule transformée avec le vecteur; un procédé de production de l'anticorps ou du fragment de liaison à l'antigène de celui-ci; une composition et une composition pour administration combinée, comprenant ledit anticorps pour la prévention ou le traitement du cancer. 본 발명은 TIGIT (T cell Immunoreceptor with Ig and Tyrosine-Based Inhibitory Motif Domains)에 대한 항체 또는 이의 항원 결합 단편, 이를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 상기 벡터로 형질전환된 세포, 상기 항체 또는 그의 항원 결합 단편의 제조방법, 이를 포함하는 암의 예방 또는 치료용 조성물 및 병용 투여용 조성물에 관한 것이다.