CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated deriva...

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Main Authors GAGNON, Kevin James, LOOKER, Adam, BOYD, Michael John, ZAKY, Mariam, GARCIA BARRANTES, Pedro Manuel, FLEMING, Gabrielle Simone, RODAY, Setu, GIACOMETTI, Robert Daniel, JOHNSON, JR, FANNING, Lev Tyler Dewey, RONKIN, Steven M, STAVROPOULOS, Kathy, KESAVAN, Sarathy, THOMSON, Stephen, JONES, Peter, SAWANT, Rupa, GUIDO, Samantha, HOOD, Sarah Carol, SWETT, Rebecca Jane, NUHANT, Philippe Marcel, SHI, Yi, SHRESTHA, Muna, MAXWELL, Brad, BOUCHER, Diane, SPOSATO, Marisa, GREY JR., Ronald Lee, BRODNEY, Michael Aaron, MEDEK, Ales, BLIGH, Cavan McKeon, OVERHOFF, Kirk Alan, HURLEY, Dennis James, CLARK, Michael Philip, MAXWELL, John Patrick, DAMAGNEZ, Veronique, XU, Jinwang, FIMOGNARI, Robert Francis, LAI, Mei-Hsiu, BANDARAGE, Upul Keerthi, HALL, Amy Beth, TAPLEY, Timothy Lewis, ROEPER, Stefanie, LIU, Siying, GIROUX, Simon, TANG, Qing
Format Patent
LanguageEnglish
French
Published 10.12.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds. L'invention concerne des composés utiles pour traiter une déficience en alpha-1 antitrypsine (AATD), selon la formule (I), des tautomères de ceux-ci, des sels pharmaceutiquement acceptables des composés, des sels pharmaceutiquement acceptables des tautomères, des dérivés deutérés des composés, des dérivés deutérés des tautomères, et des dérivés deutérés des sels, des formes solides de ces composés et des procédés de fabrication de ces composés.
Bibliography:Application Number: WO2020US32832