TRIARYL COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES

Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparati...

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Main Authors PUNNA, Sreenivas, LANGE, Christopher, SINGH, Rajinder, ZHANG, Penglie, YANG, Ju, ZENG, Yibin, MALI, Venkat Reddy, FAN, Pingchen, MALATHONG, Viengkham, MCMURTRIE, Darren
Format Patent
LanguageEnglish
French
Published 19.11.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. L'invention concerne des composés qui sont utiles en tant qu'immunomodulateurs. Les composés ont la formule (I) comprenant des stéréoisomères et des sels pharmaceutiquement acceptables de ceux-ci, R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 et n étant tels que définis dans la description. { L'invention concerne également des procédés associés à la préparation et à l'utilisation de tels composés, ainsi que des compositions pharmaceutiques comprenant de tels composés.
Bibliography:Application Number: WO2020US32904