SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

• Main Authors: MORICE, Christophe, CONTRERAS, Jean-Marie, CAMPBELL, Brian, GARRIDO, Fabrice, WITZEL, Aurelie, BELL, Ian, FELLS, James, JOSEPH, Christophe, CROWLEY, Brendan, ROECKER, Anthony, LEAVITT, Kenneth, HUFF, Belinda, PAUL, Dharam, HARVEY, Andrew John, BAZZINI, Patrick
• Format: Patent
• Language: English; French
• Published: 05.11.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure relates to compounds of formula (I) that are useful as modulators of 7α nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation. La présente invention concerne des composés de formule (I) qui sont utiles en tant que modulateurs de nAChR 7α, des compositions comprenant de tels composés, et l'utilisation de tels composés pour prévenir, traiter ou soulager une maladie, en particulier des troubles du système nerveux central tels que les troubles cognitifs de la maladie d'Alzheimer, de la maladie de Parkinson et de la schizophrénie, ainsi que de la dyskinésie induite par L-DOPA et de l'inflammation.