USE OF CHITOOLIGOSACCHARIDES FOR PROTECTING AGAINST AND TREATING DRUG-INDUCED LIVER INJURY

• Main Author: SU, Zhengquan
• Format: Patent
• Language: Chinese; English; French
• Published: 05.11.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is a use of chitooligosaccharides (COST) having a molecular weight of ≤1000 in the preparation of a composition for protecting against and treating drug-induced liver injury, particularly a composition for protecting against and treating liver injury induced by acetaminophen. Also disclosed is a method for protecting against and treating drug-induced liver injury, comprising administering an effective amount of COST to a subject having a liver injury. Experiments confirmed that COST improved abnormal biochemical indices of liver function induced by acetaminophen, significantly reduced an abnormal increase in mouse serum ALT and AST induced by acetaminophen, ameliorated liver tissue injury induced by acetaminophen, increased an amount of glutathione (GSH) as a detoxicant in a liver tissue having acetaminophen-induced liver injury, increased an anti-oxidation ability of oxidatively damaged liver induced by acetaminophen, and decreased an amount of malondialdehyde (MDA) in oxidatively damaged liver ind