COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS

Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified human immune cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer. L'invention concerne des acides nucléiques recombinés co...

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Bibliographic Details
Main Authors LIBERZON, Ella, KIEFFER-KWON, Philippe, BAEUERLE, Patrick, GETTS, Daniel, HOFMEISTER, Robert
Format Patent
LanguageEnglish
French
Published 29.10.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified human immune cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer. L'invention concerne des acides nucléiques recombinés codant pour des protéines de fusion (TFP) de récepteurs de lymphocytes T (TCR), des cellules immunitaires humaines modifiées exprimant les molécules codées, ainsi que des méthodes d'utilisation pour le traitement de maladies, dont le cancer.
Bibliography:Application Number: WO2020US29344