PROCESS FOR PREPARING 1-DEOXY-1-METHYLAMINO-D-GLUCITOL 2-(3,5-DICHLOROPHENYL)-6-BENZOXAZOLECARBOXYLATE

The present invention relates to an improved process for the preparation of 1-deoxy-1-methylamino-D- glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate, also known as tafamidis meglumine. The process of the present invention is particularly suitable for industrial scale manufacture of tafamidi...

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Bibliographic Details
Main Authors RODRÍGUEZ ROPERO, Sergio, HUGUET CLOTET, Joan
Format Patent
LanguageEnglish
French
Published 15.10.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to an improved process for the preparation of 1-deoxy-1-methylamino-D- glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate, also known as tafamidis meglumine. The process of the present invention is particularly suitable for industrial scale manufacture of tafamidis meglumine with excellent purity and high yields. La présente invention concerne un procédé amélioré pour la préparation de 1-désoxy-1-méthylamino-D-glucitol 2- (3,5-dichlorophényl)-6-benzoxazolecarboxylate, également connu sous le nom de méglumine. Le procédé de la présente invention est particulièrement approprié pour la fabrication à l'échelle industrielle de tafamidis méglumine avec une pureté excellente et des rendements élevés.
Bibliography:Application Number: WO2020EP57683