MARKER COMPOSITION FOR DIAGNOSING CANCER OR PREDICTING PROGNOSIS ON BASIS OF EXOSOME OVEREXPRESSING TUBA1C PROTEIN

• Main Authors: HONG, Sung Hoi, PARK, Yong, CHOI, Byeong Hyeon, CHOI, Yeon Ho, PARK, Ji Ho, KIM, Hyun Koo
• Format: Patent
• Language: English; French; Korean
• Published: 08.10.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

According to one embodiment of the present invention, provided are a marker composition for diagnosing cancer or predicting prognosis, comprising an exosome overexpressing a Tubulin alpha-1C chain (TUBA1C) protein, a kit, and a method for providing information necessary for diagnosing cancer or predicting prognosis, comprising a step of measuring an expression level of a TUBA1C gene or protein in an exosome isolated from a biological sample. Selon un mode de réalisation de la présente invention, l'invention concerne une composition de marqueur pour le diagnostic du cancer ou la prédiction d'un pronostic, comprenant un exosome surexprimant une protéine à chaîne tubuline alpha-1C (TUBA1C), un kit et un procédé permettant de fournir des informations nécessaires pour diagnostiquer un cancer ou prédire un pronostic, comprenant une étape de mesure d'un niveau d'expression d'un gène ou d'une protéine TUBA1C dans un exosome isolé d'un échantillon biologique. 본 발명의 일 실시예에 따르면, TUBA1C(Tubulin alpha-1C chain) 단백질 과발현 엑소좀을 포함하는, 암 진단 또는 예후 예측용 마커 조성물, 키트 및 생물학적 시료로부터 분리된 엑소좀(exosome) 내 TUBA1C 유전자 또는 단백질의 발현 수준을 측정하는 단계를 포함하는, 암의 진단 또는 예후 예측에 필요한 정보를 제공하는 방법이 제공된다.