IMMUNOLOGICAL COMPOSITION FOR DIAGNOSIS OF LUNG CANCER BY USING AUTOANTIBODY-ANTIGEN COMPLEX, DIAGNOSIS METHOD FOR LUNG CANCER BY USING SAME, AND LUNG CANCER DIAGNOSIS KIT COMPRISING SAME

• Main Authors: SONG, Keumsoo, KIM, Taisun, KIM, Junghun
• Format: Patent
• Language: English; French; Korean
• Published: 27.08.2020
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

The present invention relates to: an immunological composition for diagnosis of lung cancer, the immunological composition comprising antibody composition A containing <anti-CYFRA21-1 primary antibody-gene> and <anti-CYFRA21-1 secondary antibody-detection label> and antibody composition B containing <anti-CYFRA21-1 primary antibody-gene> and <anti-human IgG antibody-detection label>; a method for diagnosing lung cancer in a human biological sample by using same; and a lung cancer diagnosis kit using same. The composition and the method for diagnosis of lung cancer according to the present invention allow diagnosis of the onset of lung cancer in stages 0-4 with a specificity of 90% or higher and a sensitivity of 75% or higher in a non-invasive biological sample. Particularly, the composition and the method employ an autoantibody that sharply increases in concentration in the initial stage of lung cancer and as such, enable diagnosis of the onset of initial lung cancer in stages 0-1 with a sensitivity of 76% or higher. La présente invention concerne : une composition immunologique pour le diagnostic du cancer du poumon, la composition immunologique comprenant une composition d'anticorps A contenant <un anticorps anti-CYFRA21-1 primaire-gène> et <un anticorps anti-CYFRA21-1 secondaire-marqueur de détection> et la composition d'anticorps B contenant <un anticorps anti-CYFRA21-1 primaire-gène> et <un anticorps IgG anti-humain-étiquette de détection> ; un procédé de diagnostic du cancer du poumon dans un échantillon biologique humain l'utilisant ; et un kit de diagnostic du cancer du poumon l'utilisant. La composition et le procédé de diagnostic du cancer du poumon selon la présente invention permettent le diagnostic de l'apparition d'un cancer du poumon aux stades 0 à 4 avec une spécificité de 90 % ou plus et une sensibilité de 75 % ou plus dans un échantillon biologique non invasif. En particulier, la composition et le procédé utilisent un auto-anticorps dont la concentration augmente fortement à l'étape initiale du cancer du poumon et, en tant que tel, permet le diagnostic de l'apparition du cancer du poumon initial aux stades 0 et 1 avec une sensibilité de 76 % ou plus. 본 발명은 <항-CYFRA21-1 1차 항체-유전자> 및 <항-CYFRA21-1 2차 항체-측정표지>를 함유하는 항체조성물 A 및 <항-CYFRA21-1 1차 항체-유전자> 및 <항-인간 IgG 항체-측정표지>를 함유하는 항체조성물 B를 포함하는 폐암 진단용 면역학적 조성물; 이를 사용하여 인간의 생물학적 시료에서 폐암을 진단하는 방법, 및 이를 사용한 폐암 진단용 키트를 제공한다. 본 발명에 따른 폐암 진단용 조성물 및 폐암 진단 방법은, 비침습적 생물학적 시료에서 폐암 0∼4기 발병 여부를 90% 이상의 특이도와 75% 이상의 민감도로 진단할 수 있으며, 특히 폐암 초기에 농도가 급격히 증가하는 자가항체를 이용하기 때문에, 초기 폐암 0∼1기 발병 여부를 76% 이상의 민감도로 진단할 수 있다.