RECOMBINANT HEMOGLOBINS AND METHODS OF PREPARATION AND USE THEREOF

Provided are recombinant hemoglobins with improved oxygen carrying capacity and methods of preparation and use thereof. Also provided is a pharmaceutical composition including the recombinant hemoglobin useful for treating oxygen deficiency related diseases or conditions, such as stroke, hemorrhagic...

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Bibliographic Details
Main Authors WAI, Norman Fung Man, WAI, Terence Shau Yin, KWOK, Sui Yi, YU, Shan
Format Patent
LanguageEnglish
French
Published 06.08.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are recombinant hemoglobins with improved oxygen carrying capacity and methods of preparation and use thereof. Also provided is a pharmaceutical composition including the recombinant hemoglobin useful for treating oxygen deficiency related diseases or conditions, such as stroke, hemorrhagic shock, peripheral arterial disease (PAD), acute mountain sickness (AMS), cancer, and Parkinson's disease (PD). L'invention concerne des hémoglobines recombinantes ayant une capacité de transport d'oxygène améliorée et des procédés de préparation et d'utilisation de celles-ci. L'invention concerne également une composition pharmaceutique comprenant l'hémoglobine recombinante utile pour traiter des maladies ou des états liés à une déficience en oxygène, tels qu'un accident vasculaire cérébral, un choc hémorragique, une maladie artérielle périphérique (PAD), le mal de montagne aigu (AMS), le cancer et la maladie de Parkinson (PD).
Bibliography:Application Number: WO2020CN74173