PYRROLOPYRIMIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT

• Main Authors: KIM, Hyun Kyung, MA, Da Hoon, YUN, Jung Yeon, RYU, Hee Sun, KIM, Dae Kwon, JEON, Hyeon Ho, SON, Jung Beom, JUNG, Myung Ho, CHOI, Ji Eun, CHUNG, So Hyun, KIM, Hwan, KIM, Nam Doo
• Format: Patent
• Language: English; French; Korean
• Published: 23.07.2020
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pyrrolopyrimidine derivative, and a pharmaceutical composition for preventing or treating protein kinase-related disease comprising same as an active ingredient. The pyrrolopyrimidine derivative has excellent inhibitory activity against various protein kinases including LRRK2, and has an excellent effect of inhibiting proliferation of triple negative breast cancer cells. Therefore, the pharmaceutical composition comprising the pyrrolopyrimidine derivative as an active ingredient may be useful for the treatment or prevention of protein kinase-related diseases, in particular cancer, degenerative brain disease, and inflammatory disease, and specifically, may be useful for the treatment of triple negative breast cancer. La présente invention concerne un dérivé de pyrrolopyrimidine et une composition pharmaceutique pour la prévention ou le traitement d'une maladie liée à la protéine kinase le comprenant en tant que principe actif. Le dérivé de pyrrolopyrimidine a une excellente activité inhibitrice vis-à-vis de diverses protéines kinases comprenant LRRK2, et a un excellent effet d'inhibition de la prolifération de cellules du cancer du sein triple négatif. Par conséquent, la composition pharmaceutique comprenant le dérivé de pyrrolopyrimidine en tant que principe actif peut être utile pour le traitement ou la prévention de maladies liées à la protéine kinase, en particulier le cancer, une maladie cérébrale dégénérative et une maladie inflammatoire, et plus particulièrement, peut être utile pour le traitement du cancer du sein triple négatif. 피롤로피리미딘 유도체 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 피롤로피리미딘 유도체는 LRRK2를 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하고, 삼중음성 유방암 세포의 증식을 억제하는 효과가 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환, 특히, 암, 퇴행성 뇌질환 및 염증질환의 치료 또는 예방에 유용하게 사용될 수 있고, 구체적으로, 삼중음성 유방암의 치료에 유용하게 사용될 수 있다.