PYRROLOPYRIDINE DERIVATIVE AND USE THEREOF IN PREVENTION AND TREATMENT OF PROTEIN KINASE-RELATED DISEASE

• Main Authors: KIM, Hyun Kyung, MA, Da Hoon, YUN, Jung Yeon, RYU, Hee Sun, KIM, Dae Kwon, JEON, Hyeon Ho, SON, Jung Beom, JUNG, Myung Ho, CHOI, Ji Eun, CHUNG, So Hyun, KIM, Hwan, KIM, Nam Doo
• Format: Patent
• Language: English; French; Korean
• Published: 23.07.2020
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pyrrolopyridine derivative and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of a protein kinase-related disease. The pyrrolopyridine derivative has excellent inhibitory activity against various protein kinases including LRRK2, DYRK1, and CLK1 and exhibits an excellent suppressive effect on the growth of triple-negative breast cancer cells. A pharmaceutical composition comprising same as an active ingredient can be advantageously used for treating or preventing protein kinase-related diseases, inter alia, cancer, degenerative brain diseases, and inflammatory diseases, and specifically for treating triple-negative breast cancer. La présente invention concerne un dérivé de pyrrolopyridine et une composition pharmaceutique le comprenant en tant que principe actif pour la prévention ou le traitement d'une maladie liée à la protéine kinase. Le dérivé de pyrrolopyridine présente une excellente activité inhibitrice vis-à-vis de plusieurs protéines kinases notamment LRRK2, DYRK1 et CLK1 et présente un excellent effet inhibiteur sur la croissance de cellules du cancer du sein triple-négatif. Une composition pharmaceutique comprenant ledit dérivé de pyrrolopyridine en tant que principe actif peut être utilisée de manière avantageuse pour traiter ou prévenir des maladies liées à la protéine kinase, entre autres, le cancer, des maladies cérébrales dégénératives et des maladies inflammatoires, et en particulier pour traiter le cancer du sein triple-négatif. 피롤로피리딘 유도체 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 피롤로피리딘 유도체는 LRRK2, DYRK1, 및 CLK1을 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하고, 삼중음성 유방암 세포의 증식을 억제하는 효과가 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환, 특히, 암, 퇴행성 뇌질환 및 염증질환의 치료 또는 예방에 유용하게 사용될 수 있고, 구체적으로, 삼중음성 유방암의 치료에 유용하게 사용될 수 있다.