ANTI-BETA 1 INTEGRIN HUMANIZED ANTIBODY, AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING SAME

• Main Authors: LEE, Ji Chul, PARK, Jongchan, KWON, Hyeong Sun, MIN, Sung-Won
• Format: Patent
• Language: English; French; Korean
• Published: 16.07.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to a monoclonal antibody or a fragment thereof which recognizes beta 1 integrin as an antigen and thus binds specifically to same. In addition, the present invention relates to a pharmaceutical composition comprising the monoclonal antibody or a fragment thereof for preventing or treating cancer. The monoclonal antibody of the present invention suppresses the proliferation of cancer cells and angiogenesis and effectively induces apoptosis, and thus can be usefully used in preventing or treating cancer. La présente invention concerne un anticorps monoclonal ou un fragment de celui-ci qui reconnaît l'intégrine bêta 1 en tant qu'antigène et qui se lie ainsi de manière spécifique à celui-ci. De plus, la présente invention concerne une composition pharmaceutique comprenant l'anticorps monoclonal ou un fragment de celui-ci pour prévenir ou traiter le cancer. L'anticorps monoclonal selon la présente invention élimine la prolifération de cellules cancéreuses et l'angiogenèse et induit de manière efficace l'apoptose, et peut donc être utilisé de façon utile dans la prévention ou le traitement du cancer. 본 발명은 베타 1 인테그린을 항원으로 인식하여 이에 특이적으로 결합하는 단일클론항체 또는 이의 단편에 대한 것이다. 또한, 본 발명은 상기 단일클론항체 또는 이의 단편을 포함하는 암의 예방 또는 치료용 약제학적 조성물에 대한 것이다. 본 발명의 단일클론항체는 암세포의 증식 및 혈관 신생을 억제하고 세포자멸사를 효과적으로 유도하여 암의 예방 또는 치료에 유용하게 사용될 수 있다.