PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]P YRAZOLE-4-CARBOXAMIDE

The application relates to processes for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can...

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Main Authors DAHMEN, Thomas, SCHEIPERS, Claudia, SCHMITT, Harald, YIN, Jingjun, CHASSAING, Christophe, CLEATOR, Edward, SALANTA, Daniel, XIAO, Wensong, SONG, Licheng
Format Patent
LanguageEnglish
French
Published 18.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The application relates to processes for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I). L'invention concerne des procédés de préparation de 1- [(3R,4S)-4-cyanotétrahydropyran-3-yl]-3-[(2-fluoro-6-méthoxy-4-pyridyl)amino]pyrazole-4-carboxamide (I) qui comprennent (i) une synthèse d'intermédiaires de type bromopyridine et iodopyridine, (ii) une synthèse d'un intermédiaire de type ester de pyrazole qui peut être obtenu sous une forme énantiomère pure et (iii) la combinaison de ces intermédiaires en composé (I).
Bibliography:Application Number: WO2019EP84887