INSULIN ANALOGS HAVING REDUCED INSULIN RECEPTOR BINDING AFFINITY

Provided herein are insulin analogs comprising at least one mutation relative to the parent insulin, wherein the insulin analogs comprise a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid...

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Bibliographic Details
Main Authors GUESSREGEN, Stefan, KORN, Marcus Hermann, WILL, Martin, BOEHME, Thomas
Format Patent
LanguageEnglish
French
Published 18.06.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided herein are insulin analogs comprising at least one mutation relative to the parent insulin, wherein the insulin analogs comprise a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. L'invention concerne des analogues d'insuline comprenant au moins une mutation par rapport à l'insuline parente, les analogues d'insuline comprenant une mutation en position B16 qui est substituée par un acide aminé hydrophobe et/ou une mutation en position B25 qui est substituée par un acide aminé hydrophobe.
Bibliography:Application Number: WO2019EP84427