USE OF TUMOR INFLITRATING LYMPHOCYTES FOR TREATING NSCLC PATIENTS REFRACTORY FOR ANTI-PD-1 ANTIBODY

• Main Authors: FARDIS, Maria, NATARAJAN, Arvind
• Format: Patent
• Language: English; French
• Published: 25.06.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an anti -PD- 1 antibody. La présente invention concerne des processus améliorés et/ou raccourcis et des procédés de préparation de TIL afin de préparer des populations thérapeutiques de TIL ayant une efficacité thérapeutique accrue pour le traitement d'un carcinome pulmonaire non à petites cellules (CPNPC), le CPNPC étant réfractaire à un traitement avec un anticorps anti-PD-1.