RECOMBINANT PROTEIN FOR PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE AND COMPOSITION COMPRISING SAME FOR PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE

• Main Authors: HAN, Choongseong, KIM, Jonghoon, WOO, Donghun, KANG, Hoyoung, PARK, Donghyuk
• Format: Patent
• Language: English; French; Korean
• Published: 30.04.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a recombinant protein for prevention or treatment of Alzheimer's disease, which is recombined on the basis of milk fat globule-EGF factor 8(MFG-E8) protein and has the amino acid sequence of SEQ ID NO: 1. The recombinant protein can delay the onset of Alzheimer's disease or slow down the progression of the disease and further can provide an effect of restoring symptoms associated with degeneration in memory, cognition, and behavior to normal levels. In addition, the present invention relates to a pharmaceutical composition comprising as an active ingredient a recombinant protein for prevention or treatment of Alzheimer's disease, which is recombined on the basis of milk fat globule-EGF factor 8 (MFG-E8) protein and has the amino acid sequence of SEQ ID NO: 1. La présente invention concerne une protéine recombinante pour la prévention ou le traitement de la maladie d'Alzheimer, qui est recombinée sur la base de la protéine du globule gras du lait de facteur de croissance 8 (MFG-E8) et possède la séquence d'acides aminés représentée par SEQ ID NO : 1. La protéine recombinante peut retarder l'apparition de la maladie d'Alzheimer ou ralentir la progression de la maladie, et peut en outre apporter comme effet une restauration à des niveaux normaux des symptômes associés à la dégénérescence de la mémoire, de la cognition et du comportement. De plus, la présente invention concerne une composition pharmaceutique comprenant comme principe actif une protéine recombinante pour la prévention ou le traitement de la maladie d'Alzheimer, qui est recombinée sur la base de la protéine du globule gras du lait de facteur de croissance 8 (MFG-E8) et possède la séquence d'acides aminés représentée par SEQ ID NO : 1. 본 발명은 Milk fat globule-EGF factor 8(MFG-E8) 단백질을 기반으로 재조합된 알츠하이머병 예방 또는 치료용 재조합 단백질로서, 서열번호1의 아미노산 서열로 이루어져 알츠하이머병의 발병을 지연시키거나 질환의 진행 속도를 늦출 수 있으며, 더 나아가 기억능력, 사고능력 및 행동능력의 퇴행과 관련된 증상을 정상 수준으로 회복시킬 수 있는 효과를 제공할 수 있다. 아울러, 본 발명은 서열번호1의 아미노산 서열로 이루도록 Milk fat globule-EGF factor 8(MFG-E8) 단백질을 기반으로 재조합된 알츠하이머병 예방 또는 치료용 재조합 단백질을 유효성분으로 포함하는 약학 조성물에 관한 것이기도 하다.