THERAPEUTIC COMPOUNDS

The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment o...

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Main Authors RAY, Nick Charles, RUSSELL, Michael Geoffrey Neil, ROUSSEL, Fabien Jean Ghislain, LUCAS, Cathy Louise, CRUMPLER, Simon Ross, YEAP, Siew Kuen, EVANS, David Gareth, MARTIN, Barrie Phillip, NOWAK, Thorsten, LE BOZEC, Lucille, SEHMI, Sanjeet Singh, CRICK, Duncan James, HYND, George, BLANEY, Emma Louise, SEWARD, Eileen Mary
Format Patent
LanguageEnglish
French
Published 30.04.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation. La présente invention concerne des composés qui sont des activateurs de Nrf2. Les composés ont la formule structurale I définie dans la description. La présente invention concerne également des procédés pour la préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de maladies ou de troubles associés à l'activation de Nrf2.
Bibliography:Application Number: WO2019GB53012