HYDROGELS WITH TUNABLE ELECTROSTATIC PROPERTIES

Disclosed herein is a sustained release composition comprising an active agent having a positive or a negative charge when placed in an aqueous environment, and a crosslinked hydrogel tuned to have an overall charge that facilitates electrostatic interaction between the crosslinked hydrogel and the...

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Bibliographic Details
Main Authors TAN, Thatt Yang Timothy, CHUN, Yong Yao, SEET, Li Fong, WONG, Tzee Ling Tina
Format Patent
LanguageEnglish
French
Published 12.03.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein is a sustained release composition comprising an active agent having a positive or a negative charge when placed in an aqueous environment, and a crosslinked hydrogel tuned to have an overall charge that facilitates electrostatic interaction between the crosslinked hydrogel and the active agent, wherein the crosslinked hydrogel is formed from a heterobifunctional polymer (e.g. gelatin) and a heterobifunctional crosslinking agent (e.g. tyramine or hydroxyphenyl propionic acid). L'invention concerne une composition à libération prolongée comprenant un agent actif ayant une charge positive ou négative lorsqu'il est placé dans un environnement aqueux, et un hydrogel réticulé ajusté pour avoir une charge globale qui facilite l'interaction électrostatique entre l'hydrogel réticulé et l'agent actif, l'hydrogel réticulé étant formé à partir d'un polymère hétérobifonctionnel (par exemple, la gélatine) et d'un agent de réticulation hétérobifonctionnel (par exemple, la tyramine ou l'acide hydroxyphényl propionique).
Bibliography:Application Number: WO2019SG50448