GROUP OF GENES FOR MOLECULAR TYPING OF MEDULLOBLASTOMA AND USE THEREOF

• Main Authors: SUN, Yifeng, XU, Qinghua, CHEN, Chengshu, SONG, Kaibin, WANG, Qifeng, CHEN, Jinying
• Format: Patent
• Language: Chinese; English; French
• Published: 12.03.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A group of genes for molecular typing of medulloblastoma, comprising the following 24 genes: EPHA7 gene, OTX2 gene, ROBO1 gene, TTR gene, LGR5 gene, IGF2BP3 gene, TBR1 gene, ZFPM2 gene, TRDC gene, TRAC gene, PEX5L gene, NKD1 gene, RALYL gene, GABRA5 gene, GAD1 gene, TNC gene, KCNA1 gene, EOMES gene, MAB21L2 gene, WIF1 gene, DKK2 gene, PDLIM3 gene, IMPG2 gene, and KHDRBS2 gene. Use of the described genes in the preparation of kits and gene chips for molecular typing of medulloblastoma. Upon verification, the described genes can accurately differentiate WNT type, SHH type, Group3 type and Group4 type of medulloblastoma, and the results are objective, and have high accuracy, and the experimental cycle is short, and thus the genes have important clinical significance for accurate treatment of a patient. L'invention concerne un groupe de gènes pour le typage moléculaire de médulloblastome, comprenant les 24 gènes suivants : gène EPHA7, gène OTX2, gène ROBO1, gène TTR, gène LGR5, gène IGF2BP3, gène TBR1, gène ZFPM2