DIRECTED PSEUDOURIDYLATION OF RNA

Described herein are compositions, systems, methods, and kits utilizing CRISPR-Cas protein fusions comprising a guide nucleotide sequence-programmable RNA binding protein and a RNA pseudouridylation modification protein. The compositions, systems, methods, and kits described herein are useful to mod...

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Bibliographic Details
Main Authors BRANNAN, Kristopher, YEO, Eugene
Format Patent
LanguageEnglish
French
Published 05.03.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Described herein are compositions, systems, methods, and kits utilizing CRISPR-Cas protein fusions comprising a guide nucleotide sequence-programmable RNA binding protein and a RNA pseudouridylation modification protein. The compositions, systems, methods, and kits described herein are useful to modulate RNA pseudouridylation. La présente invention concerne des compositions, des systèmes, des procédés et des kits utilisant des fusions de protéines CRISPR-Cas comprenant une protéine de liaison à l'ARN programmable par séquence nucléotidique de guidage et une protéine de modification de pseudouridylation de l'ARN . Les compositions, les systèmes, les procédés et les kits selon la présente invention sont utiles pour moduler la pseudouridylation de l'ARN.
Bibliography:Application Number: WO2019US49182