SUBSTITUTED PYRAZOLE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF

A substituted pyrazole compound represented by formula I, and a preparation method, a pharmaceutical composition, and use thereof. The compound has good stability, excellent solubility, small cell toxicity, and a significant effect on neuroprotection, can effectively prevent and treat nerve cell dam...

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Bibliographic Details
Main Authors HAN, Jianbin, YANG, Liu, WEN, Xiang, LI, Zedong, YANG, Jinna
Format Patent
LanguageChinese
English
French
Published 27.02.2020
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:A substituted pyrazole compound represented by formula I, and a preparation method, a pharmaceutical composition, and use thereof. The compound has good stability, excellent solubility, small cell toxicity, and a significant effect on neuroprotection, can effectively prevent and treat nerve cell damages, and is an ideal pharmaceutical compound for preventing or treating cerebral apoplexy, cerebral embolism, cerebral apoplexy sequelae, cerebral apoplexy motion dysfunction, mitochondria brain myopathy, and amyotrophic lateral sclerosis. (I) La présente invention concerne un composé pyrazole substitué représenté par la formule (I), et un procédé de préparation, une composition pharmaceutique, et une utilisation associée. Le composé présente une bonne stabilité, une excellente solubilité, une faible toxicité cellulaire, et un effet significatif sur la neuroprotection, peut efficacement prévenir et traiter les détériorations des cellules nerveuses, et est un composé pharmaceutique idéal pour prévenir ou traiter l'
Bibliography:Application Number: WO2019CN100835