IMPROVED DETECTION OF NUCLEASE EDITED SEQUENCES IN AUTOMATED MODULES AND INSTRUMENTS VIA BULK CELL CULTURE

The present disclosure provides methods, automated modules, and instruments for enrichment of live cells that have been edited by nucleic acid-guided nuclease genome editing. The disclosure provides improved methods and modules-including high throughput methods and modules-for enriching for cells th...

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Bibliographic Details
Main Authors HIDDESSEN, Amy, DAVIS, Clint, BELGRADER, Phillip, JOHNSON, Charles, SPINDLER, Eileen
Format Patent
LanguageEnglish
French
Published 20.02.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure provides methods, automated modules, and instruments for enrichment of live cells that have been edited by nucleic acid-guided nuclease genome editing. The disclosure provides improved methods and modules-including high throughput methods and modules-for enriching for cells that have been subjected to editing. La présente invention concerne des procédés, des modules automatisés et des instruments pour l'enrichissement en cellules vivantes qui ont été éditées par une édition de génome par nucléase guidée par un acide nucléique. L'invention concerne des procédés et des modules - comprenant des procédés à haut rendement et des modules - pour l'enrichissement en cellules qui ont été soumises à une édition.
Bibliography:Application Number: WO2019US46526