PRMT5 INHIBITORS

The present invention provides a compound of formula (I) Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, are PRMT5 inhibitors. Also provided are methods of making compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I), and metho...

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Main Authors HUANG, Chunhui, MACHACEK, Michelle, SCHNEIDER, Sebastian, KAWAMURA, Shuhei, WITTER, David, WAN, Murray
Format Patent
LanguageEnglish
French
Published 13.02.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a compound of formula (I) Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, are PRMT5 inhibitors. Also provided are methods of making compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I), and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations. La présente invention concerne un composé de formule (I) et les sels, esters et promédicaments pharmaceutiquement acceptables de celui-ci, qui sont des inhibiteurs de PRMT5. L'invention concerne également des procédés de fabrication de composés de formule (I), des compositions pharmaceutiques comprenant des composés de formule (I), et des procédés d'utilisation de ces composés pour traiter le cancer, la drépanocytose et la persistance héréditaire de mutations d'hémoglobine foetale (HPFH).
Bibliography:Application Number: WO2019US45043