GFRAL EXTRACELLULAR DOMAINS AND METHODS OF USE

GFRAL extracellular domains comprising domains D2 and D3 are disclosed. The disclosure further relates to methods and compositions for screening and evaluating the activity of a GFRAL ligand, such as a GDF15 peptide, using the GFRAL extracellular domains provided herein. Also disclosed are methods a...

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Bibliographic Details
Main Authors HELDWEIN, Kurt Alex, LINDSLEY, Loren Daniel, BAI, Jirong
Format Patent
LanguageEnglish
French
Published 13.02.2020
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Summary:GFRAL extracellular domains comprising domains D2 and D3 are disclosed. The disclosure further relates to methods and compositions for screening and evaluating the activity of a GFRAL ligand, such as a GDF15 peptide, using the GFRAL extracellular domains provided herein. Also disclosed are methods and compositions for treating obesity, reducing appetite, and/or reducing body weight using the GFRAL extracellular domains provided herein. L'invention concerne des domaines extracellulaires GFRAL comprenant des domaines D2 et D3. L'invention concerne en outre des procédés et des compositions pour cribler et évaluer l'activité d'un ligand GFRAL, tel qu'un peptide GDF15, à l'aide des domaines extracellulaires GFRAL décrits ici. L'invention concerne également des procédés et des compositions pour traiter l'obésité, réduire l'appétit, et/ou réduire le poids corporel à l'aide des domaines extracellulaires GFRAL décrits ici.
Bibliography:Application Number: WO2019IB56803