HA-1 SPECIFIC T CELL RECEPTORS AND THEIR USE

The present invention covers an isolated T cell receptor (TCR) specific for one allelic variant of minor histocompatibility antigen 1 (HA-l), in particular the allelic variant HA-lH. An isolated polypeptide comprising a functional portion of the TCR is also described. Moreover, a multivalent TCR com...

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Bibliographic Details
Main Authors SOMMERMEYER, Daniel, BRACHER, Aline, ELLINGER, Christian
Format Patent
LanguageEnglish
French
Published 13.02.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention covers an isolated T cell receptor (TCR) specific for one allelic variant of minor histocompatibility antigen 1 (HA-l), in particular the allelic variant HA-lH. An isolated polypeptide comprising a functional portion of the TCR is also described. Moreover, a multivalent TCR complex, nucleic acid molecules, vectors, cells, antibodies as well as medical uses that relate to the TCR are defined. La présente invention couvre un récepteur de lymphocyte T (TCR) isolé spécifique d'un variant allélique d'antigène d'histocompatibilité mineure 1 (HA-1), en particulier le variant allélique HA-1H. L'invention concerne également un polypeptide isolé comprenant une partie fonctionnelle du TCR. De plus, un complexe TCR multivalent, des molécules d'acide nucléique, des vecteurs, des cellules, des anticorps ainsi que des utilisations médicales qui se rapportent au TCR sont décrits.
Bibliography:Application Number: WO2019EP71099